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Genomic Messages电子书

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296人正在读 | 0人评论 6.2

作       者:Annas, George

出  版  社:HarperOne

出版时间:2015-06-23

字       数:212.6万

所属分类: 进口书 > 外文原版书 > 励志自助/心灵

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Ready or not, medical practice is changing. Advances in the field of genomics—the study of how our DNA is constructed and functions—have made it easier for physicians to diagnose, treat, and even predict today's many pressing health concerns. With the emergence of genomic sequencing and DNA analysis, this is an exciting moment in science, medicine, and personal health.But it's also an uncertain time, one fraught with understandable and uncomfortable questions:Can we take advantage of genomic progress and avoid genomic discriminationCan medicine be tailored to a patient's unique DNA profileHow will DNA banks and electronic medical records affect our privacy and welfareShould we screen our healthy child's DNAWhen is information too much information?In Genomic Messages, George Annas, j.d., m.p.h., and Sherman Elias, M.D., a health lawyer/bioethicist and an obstetrician-gynecologist/geneticist, respectively, answer these and other pressing questions about genomics. Together, they detail the field’s past, present, and future, while laying out its myriad legal, medical, and ethical ramifications. They empower individuals and families with the knowledge to make better decisions about their short-term and long-term health.Comprehensive, accessible, and revolutionary, Genomic Messages is the definitive guide to genomics, personalized medicine, and the future of healthcare.
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Dedication

Contents

Introduction

1. The Coming Flood of Genomic Messages

What is genomic information?

What is genomic privacy?

What is genomic medicine and why might it change how we think?

Can we strike a “genetic balance” in our health care?

2. Personalized (Genomic) Medicine

What is a genetic family history and why does it matter?

How can personalized medicine become impersonal medicine?

How did genetically isolated populations help DNA researchers?

Why will genomic medicine require electronic health records?

3. Nature, Nurture, and the Microbiome

How do twins help us understand that it’s nature and nurture?

How do genomics and the environment work in diabetes?

How does your microbiome affect your health?

4. Pharmacogenomics

How have racism and stereotyping plagued genomics?

What does warfarin tell us about pharmacogenomics?

How do foods and genes interact?

Why is it unlikely that your physician will use your genome to prescribe drugs?

What will pharmacogenomics look like in the future?

5. Reprogenomics

Why is reprogenomics based on genetic relationships?

What are the social policy issues in reprogenomics?

What new issues do embryo and stem cell research create?

Is regulation of the fertility industry necessary?

6. Genomic Messages from Fetuses

How does prenatal diagnosis work?

What are karyotypes and microarrays?

Is whole-genome sequencing of fetuses in our future?

7. Genomic Messages from Newborns and Children

When is whole-genome sequencing of sick children indicated?

What is newborn screening and how does it work?

Why shouldn’t all newborns have their DNA sequenced?

8. Cancer Genomics

Is cancer a genetic disease?

How can the “hallmarks of cancer” suggest novel treatments?

Why does cancer sequencing hold promise for personalized medicine?

9. Genomic Privacy and DNA Data Banks

How do “big data” and “big DNA banks” affect our privacy?

How do criminal DNA data banks work?

How do commercial DNA data banks work?

How can we make informed consent to DNA data banking meaningful?

Can companies patent our DNA?

10. Genomics Future

How does genomics affect how we see death and our future?

What are “species-endangering” experiments?

What are “posthumans” and “transhumans”?

How can we tell the difference between genomics fact and fantasy?

How can individuals influence the genomics research agenda?

Acknowledgments

Appendix A: DNA and the Human Genome

Appendix B: Limitations of Screening Tests

Notes

Glossary

Index

Copyright

About the Publisher

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