The riveting true story of John and Aileen Crowley's race to find a cure for Pompe disease that inspired the movie Extraordinary Measures With three beautiful children, a new house, and financial security, John and Aileen Crowley were on top of the world until their two youngest children, fifteen-month-old Megan and five-month-old Patrick, were diagnosed with Pompe disease and given only months to live. Refusing to accept a death sentence, John quit his financial consultant job and invested his life savings in a biotechnology start-up to research the disease and find a cure. Battling scientific setbacks, conflict of interest accusations, and business troubles, John and Aileen would be tested to their limits as they valiantly fought, and succeeded, in finding revolutionary new treatment for the disease offering hope to Megan, Patrick, and the many children and families affected by Pompe disease around the world. The inspiration for the captivating film Extraordinary Measures , starring Brendan Fraser and Harrison Ford, The Cure is a remarkable true story of cutting-edge science, business acumen and daring, and one family's indomitable spirit.

Will I Ever Find My Soul MateWhether you are recently separated, divorced, or you have been in the singles scene for longer than you want, this insightful guide will help you navigate the dating maze and find that special person you've been waiting for. By discussing the differences between men and women, Mars and Venus on a Date provides singles with: A thorough understanding of the five stages of dating -- attraction, uncertainty, exclusivity, intimacy, and engagement How to know what kind of person is right for you Answers to burning questions such as why don't men call, or why do some women stay singleThe best places to meet your soul mate And advice on creating a loving and mutually fulfilling relationship Filled with practical guidelines, inventive techniques, and witty insight, Mars and Venus on a Date will help single men and women explore the world of dating, understand how to make good choices, and discover the secret to finding a soul mate.

轻松幽默爱情喜剧：得知城市的女性比男性要多得多，单身的凯蒂决定放弃城市生活，来到偏僻的苏格兰高地小镇——一个男人众多的地方——寻找爱情，她能成功吗？ From New York Times?bestselling author Jenny Colgan comes this hilarious romance about a woman?who?trades in the comforts of city life in hopes of finding love in a small Scottish town in the middle of nowhere.Faced with the harsh reality that there are 25,000 more women than men in London, Katie’s dating prospects are at an all-time low. While she’s glad it’s not a man’s world anymore, it wouldn’t hurt if there were more eligible bachelors. ?More likely to get murdered than married, according to gleeful media reports, Katie resigns herself to the fact that there’s no sex in the city for her and decides to head for the hills—or the Scottish Highlands to be exact. Despite the fact she’s never been one for muddy rain boats—and Fairlish is in the middle of nowhere—the tiny town does have one major draw: men. LOTS of them!But while Katie relishes the chance to do battle with armies of admirers, she’s not excited about going head to head with her shady new boss, Harry. At least there’s the local eye-candy to distract her, including gorgeous newshound Iain. But he is at loggerheads with Harry, and she can’t afford to get on Harry’s bad side any more than she already has.Life in the country might not be one big roll in the hay, but now that Katie has taken the plunge, can she ever turn her back on the delights of Fairlish and return to city life…?

The Fast and the Furious meets Transformers in the second book of this high-stakes series about twelve-year-old Mace Blazer, who pilots state-of-the-art vehicles that transform seamlessly to race on the road, in the air, and even underwater. Mace Blazer is the world’s hottest TURBOnaut. Compared to the other ‘nauts, he drives faster, dares harder, and pulls the craziest stunts. Since he won the Gauntlet Prix and revealed that he’s only twelve, the world has been screaming Mace’s name.Now nothing—not even his friends and family—can hold Mace back from becoming the greatest racer of all time. But when Mace suffers a nearly fatal accident while behind the wheel, he loses the nerve that made him the best. He’s done with driving fast. He’s done with TURBO. Until he finds out that his two best friends have mysteriously disappeared as part of a sinister plot that could destroy not just TURBO, but the world. Mace has no choice but to buckle back in, swallow his fears, and race to save the day. In the thrilling sequel to TURBO Racers: Trailblazer, Mace will have to decide if he’s willing to risk everything to save the sport, and the people, that he loves. Every morph matters in this heart-pounding, exhilarating adventure series by acclaimed author Austin Aslan.

Five years after escaping into the mountains of North Carolina, Eric Rudolph was becoming a figure of folk legend. The FBI had long since abandoned its manhunt the largest ever on U.S. soil for the fugitive accused of bombing the Atlanta Olympics, two abortion clinics, and a gay bar. Then, one night, Rudolph got careless; he was arrested and put in jail possibly forever. But even in custody, he remained unrepentant . . . and an enigma.In Lone Wolf, Maryanne Vollers brings the reader deep inside one of the most sensational cases of domestic terrorism in American history. At the same time, without losing sight of the hideous nature of Rudolph's violent crimes, she successfully puts a human face on an iconic killer while exploring the painful mysteries of the heart.

This unique book supports parents who are struggling with the heartache of having a teenager or an adult child who is troubled, angry, or distant. Such rifts can cause unspeakable sorrow that parents too often must bear alone. Psychologist and parent Coleman, Ph.D., offers insight, empathy, and perspective to those who have lost the opportunity to be the parent they desperately wanted to be and who are mourning the loss of a harmonious relationship with their child. Through case examples and healing exercises, Dr. Coleman helps parents: Reduce anger, guilt, and shame Learn how temperament, the teen years, their own or a partner's mistakes, and divorce can strain the parent-child bond Come to terms with their own and their child's imperfections Maintain self-esteem through difficult times Develop strategies for rebuilding the relationship or move toward acceptance of what can't be changed Understand how society's high expectations of parents contribute to the risk of parental wounds By helping parents recognize what they can do, and let go of what they cannot, Dr. Coleman helps families develop more positive ways of healing themselves and relating to each other.

Parental anxiety is at an all-time high, and with parenting styles swinging from attachment parenting to that of "Tiger Moms," Robin Berman, MD, inspires mothers and fathers to find a graceful place in the middle.Children used to be seen and not heard, but now they are at the center of their parents' universe. Parents today seem skittish about asserting their authority. They indulge in their children's demands and tantrums, and enter into endless negotiations, all for fear of hurting their children's feelings. Sadly, this indulgence is creating a generation of psychologically fragile individuals, and it undermines the very self-esteem it seeks to build. In between these parenting extremes lies a better way to raise thriving, well-adjusted children.Parents need to know that it is not only OK but essential to be in charge. Children with too much power often become anxious, and not allowing children to work through negative emotions leads to a lack of resilience later in their lives.Permission to Parent teaches parents to be comfortable setting boundaries while maintaining a loving connection, fostering self-esteem, respect, and emotional maturity. Children need limits more than they need indulgences, time more than schedules, and love more than stuff.Robin Berman, MD, provides the tools for great parenting by drawing from her extensive clinical experience and wisdom collected from seasoned therapists, revered teachers, and role-model parents. Permission to Parent strikes the perfect balance of advice, anecdote, and research to be an essential parenting guide.

Cokie Roberts's number one New York Times bestseller, We Are Our Mothers' Daughters, examined the nature of women's roles throughout history and led USA Today to praise her as a "custodian of time-honored values." Her second bestseller, From This Day Forward, written with her husband, Steve Roberts, described American marriages throughout history, including the romance of John and Abigail Adams. Now Roberts returns with Founding Mothers, an intimate and illuminating look at the fervently patriotic and passionate women whose tireless pursuits on behalf of their families -- and their country -- proved just as crucial to the forging of a new nation as the rebellion that established it.While much has been written about the men who signed the Declaration of Independence, battled the British, and framed the Constitution, the wives, mothers, sisters, and daughters they left behind have been little noticed by history. Roberts brings us the women who fought the Revolution as valiantly as the men, often defending their very doorsteps. While the men went off to war or to Congress, the women managed their businesses, raised their children, provided them with political advice, and made it possible for the men to do what they did. The behind-the-scenes influence of these women -- and their sometimes very public activities -- was intelligent and pervasive.Drawing upon personal correspondence, private journals, and even favored recipes, Roberts reveals the often surprising stories of these fascinating women, bringing to life the everyday trials and extraordinary triumphs of individuals like Abigail Adams, Mercy Otis Warren, Deborah Read Franklin, Eliza Pinckney, Catherine Littlefield Green, Esther DeBerdt Reed, and Martha Washington -- proving that without our exemplary women, the new country might never have survived.Social history at its best, Founding Mothers unveils the drive, determination, creative insight, and passion of the other patriots, the women who raised our nation. Roberts proves beyond a doubt that like every generation of American women that has followed, the founding mothers used the unique gifts of their gender -- courage, pluck, sadness, joy, energy, grace, sensitivity, and humor -- to do what women do best, put one foot in front of the other in remarkable circumstances and carry on.

Why does Oklahoma have that panhandleDid someone make a mistakeWe are so familiar with the map of the United States that our state borders seem as much a part of nature as mountains and rivers. Even the oddities the entire state of Maryland(!) have become so engrained that our map might as well be a giant jigsaw puzzle designed by Divine Providence. But that's where the real mystery begins. Every edge of the familiar wooden jigsaw pieces of our childhood represents a revealing moment of history and of, well, humans drawing lines in the sand.How the States Got Their Shapes is the first book to tackle why our state lines are where they are. Here are the stories behind the stories, right down to the tiny northward jog at the eastern end of Tennessee and the teeny-tiny (and little known) parts of Delaware that are not attached to Delaware but to New Jersey. How the States Got Their Shapes examines: Why West Virginia has a finger creeping up the side of Pennsylvania Why Michigan has an upper peninsula that isn't attached to Michigan Why some Hawaiian islands are not Hawaii Why Texas and California are so outsized, especially when so many Midwestern states are nearly identical in size Packed with fun oddities and trivia, this entertaining guide also reveals the major fault lines of American history, from ideological intrigues and religious intolerance to major territorial acquisitions. Adding the fresh lens of local geographic disputes, military skirmishes, and land grabs, Mark Stein shows how the seemingly haphazard puzzle pieces of our nation fit together perfectly.

New York Times bestselling author Philip Carlo, one of the foremost chroniclers of the New York Mafia and the criminal mind, returns with a shocking exploration of his most twisted and notorious villain yet Tommy "Karate" Pitera was not like other mafiosi. He was not only a capo in the notorious Bonanno family but also a devoted student of crime a deadly martial artist who'd been trained in Japan as a teenager. Highly skilled with knives and other lethal weapons, dressed entirely in black, Pitera murdered his way to becoming one of the premier assassins in New York City during the 1980s he even killed at the behest of John Gotti.Remorseless and deadly, Pitera took human lives as if he had a God-given right, while at the same time dealing high-grade Sicilian heroin and South American cocaine. There were numerous men within the New York Mafia who killed people, men who weren't afraid of anyone or anything, but all of them looked the other way when they saw Pitera coming. Word on the street was that he didn't just whack people; he made them disappear forever. In hushed whispers people spoke of Pitera's secret burial grounds and the grotesque things he did to his victim's bodies. If the Mafia had a Jeffrey Dahmer, it was surely Tommy Pitera.Like his father and grandfather before him, Jim Hunt had a gift for bringing down bad guys. During Hunt's stellar career at the DEA, he had arrested his share of criminals and had caught many of the elusive drug lords of New York City. But nothing could have prepared him for what he encountered when he and his elite antidrug unit began investigating Tommy Pitera. What started as a routine investigation into a cocaine and heroin ring in Bensonhurst, Brooklyn, grew exponentially as Hunt and his team uncovered the layers of death that surrounded Pitera. Through carefully placed wiretaps, dangerous stakeouts, and fearful informants, Hunt managed to turn Pitera's few confidants against him, but not before Pitera had killed an estimated sixty people.Offering the first-ever look at the life and crimes of Tommy "Karate" Pitera, New York Times bestselling author Philip Carlo exposes the man behind some of the most horrific murders in Mafia history and the heroic investigator who brought him down. Getting inside the minds of both killer and detective, Carlo masterfully details the delicate and deadly game of cat-and-mouse that resulted in the capture of a Mafia killer unlike any other. A tale of murder, drugs, money, and ultimately justice, The Butcher is Carlo's most frightening portrayal yet of the depraved depths within a psychopath's mind.

Warrick Dunn was only eighteen when his mother, a Baton Rouge police officer, was shot and killed. Yet somehow he managed to enroll at Florida State University and help his team to a national championship during his freshman year while also caring for his five brothers and sisters. Despite his modest size, Dunn went on to a storied NFL career with the Tampa Bay Buccaneers and the Atlanta Falcons, becoming one of only twenty-three running backs in NFL history to exceed the 10,000-yard career rushing mark. Off the field, he created the Warrick Dunn Foundation and its Homes for the Holidays program, helping single parents achieve first-time home ownership. But in his drive to help others, the one person Dunn neglected was himself, as the pain of his mother's loss led to a spiraling depression that went untreated for years.Running for My Life details Dunn's struggle to confront his past and face the grief that consumed him for far too long. Thought-provoking and uplifting, it is the story of an exceptional athlete's secret torment and inspiring courage.

Baseball was different in earlier days tougher, rawer, more intimate when giants like Babe Ruth and Ty Cobb ran the bases. In the monumental classic The Glory of Their Times, the golden era of our national pastime comes alive through the vibrant words of those who played and lived the game.

A profound expansion of David McCullough, Jr.'s popular commencement speech a call to arms against a prevailing, narrow, conception of success viewed by millions on YouTube You Are (Not) Special is a love letter to students and parents as well as a guide to a truly fulfilling, happy life.Children today, says David McCullough high school English teacher, father of four, and son and namesake of the famous historian are being encouraged to sacrifice passionate engagement with life for specious notions of success. The intense pressure to excel discourages kids from taking chances, failing, and learning empathy and self-confidence from those failures.In You Are (Not) Special, McCullough elaborates on his now-famous speech exploring how, for what purpose, and for whose sake, we're raising our kids. With wry, affectionate humor, McCullough takes on hovering parents, ineffectual schools, professional college prep, electronic distractions, club sports, and generally the manifestations, and the applications and consequences of privilege. By acknowledging that the world is indifferent to them, McCullough takes pressure off of students to be extraordinary achievers and instead exhorts them to roll up their sleeves and do something useful with their advantages.

Fans of John Leguizamo's smash-hit one-man shows (Mambo Mouth, Spic-o-rama, Freak, and Sexaholix) have already gotten a glimpse into his life, but this book tells the whole story, carrying readers along on a wild journey from his childhood in Queens to his current home at the top of the Hollywood pyramid. An acclaimed director, producer, and play-wright, and one of the highest-paid Latin actors in the world, Leguizamo shares the stories behind his many roles what inspired them and what transpired as he created them while dishing on his personal relationships with his family, friends, and celebrity colleagues. Here is both an intimate self-portrait and a unique behind-the-scenes look at the magic and chaos of stardom, a keenly intelligent and insanely funny book that celebrates a remarkably talented artist's greatest achievement: growing up Latino in America and succeeding on his own terms.

"I have listened and I have been quiet all my life. But now I will speak."One of the world's foremost experts on terrorism and post-traumatic stress disorder investigates her own unsolved adolescent sexual assault at the hands of a serial rapist, and in so doing, examines the horrors of trauma and denial. Alone in an unlocked house in a safe neighborhood in the suburban town of Concord, Massachusetts, two good, obedient girls, Jessica Stern, fifteen, and her sister, fourteen, were raped on the night of October 1, 1973. The girls had just come back from ballet lessons and were doing their homework when a strange man armed with a gun entered their home. Afterward, when they reported the crime, the police were skeptical.The rapist was never caught. For over thirty years, Stern denied the pain and the trauma of the assault. Following the example of her family, Stern who lost her mother at the age of three, and whose father was a Holocaust survivor focused on her work instead of her terror. She became a world-class expert on terrorism, a lauded academic and writer who interviewed terrorists around the globe. But while her career took off, her success hinged on her symptoms. After her ordeal she could not feel fear in normally frightening situations.Stern believed she'd disassociated from the trauma altogether, until a devoted police lieutenant reopened the sisters' rape case and brought her back to that harrowing night more than three decades past. With the help of the lieutenant, Stern began her own investigation bringing to bear all her skills as a researcher to uncover the truth about the town of Concord, her family, and her own mind. The result is Denial, a candid, courageous, and ultimately hopeful look at a trauma and its aftermath.

Warning! New parents are likely to experience:Scorekeeping An exceedingly complex, often relentless, tit-for-tat war waged by husbands and wives over the division of parenting responsibilities and domestic chores. The Ten O'Clock Shoulder Tap Considered by many men to be a form of foreplay. A paw on a wife's shoulder is how some men indicate their desire for sex. The Tap is rarely accompanied by a term of endearment or any other verbal form of communication and is seldom well received by the often-sleeping/almost-always-exhausted wife. The frustrated husband, meanwhile, wonders if his wife has pulled a Bait and Switch in the bedroom.Clash of the Grannies A high stakes "who will have the greatest influence on the grandkids" tournament played by each set of grandparents. Competitive categories include: the Title Championship (who gets to be called "Grandma"), the Battle for Floor and Wall Space, the Battle for Face Time, and Gratuitous Grandparental Gift-Giving. The Babyproofers are three women who wouldn't trade their roles as mothers for anything, and they love their husbands deeply. But after living through it and hearing the stories of hundreds of other couples, they know that with young children in the house, you need to block the stairs with baby gates, put plastic covers over the outlets, AND take the necessary steps to safeguard your marriage. Babyproofing Your Marriage is the warts-and-all truth about how having children can affect your relationship. The authors explore the transition to parenthood in light of their own experiences, with input from their husbands and commentary from men and women across the country. Their evenhanded approach to both sides of the marital equation allows spouses to understand each other in a whole new way. With loads of humor and practical advice, the Babyproofers will guide first-time parents and veterans alike around the rocky shores of the early parenting years. Don't fall prey to common relationship pitfalls: Babyproof Your Marriage!

In his inimitable New York voice, Pulitzer Prize winner Jimmy Breslin gives us a look through the keyhole at the people and places that define the Mafia characters like John Gotti, Sammy "the Bull" Gravano, Anthony "Gaspipe" Casso (named for his weapon of choice), and Jimmy "the Clam" Eppolito interwoven with the remarkable true-crime saga of the good rat himself, Burt Kaplan of Bensonhurst, Brooklyn, the star witness in the recent trial of two NYPD detectives indicted for carrying out eight gangland executions. Through these unforgettable real-life and long-forgotten Mafia stories, Jimmy Breslin captures the moments in which the mob was made and broken.

This game-changing book empowers readers to become confident, independent, wise decision-makers— savvy to how our emotions, moods, and habits can trip us up. An investor wonders whether to put his money into the stock market or to keep it in a savings account. A patient is torn between opting for surgery and trying an experimental drug therapy. A college-bound student questions whether to take on debt to attend an Ivy League school or to choose a public institution with low tuition. We face momentous decisions with important consequences throughout our lives. We have never had better access to information and expertise, yet this data deluge has become a double-edged sword. Which sources of information are credibleHow can we separate the signal from the noiseWhose advice can we trustAll of these questions are reasons for us to become empowered decision-makers capable of making high-stakes choices ourselves. Whether you are a politician, a businessperson, a professional, or a parent, now is the time to take a radically different approach. In Eyes Wide Open, the bestselling author and visionary thinker Noreena Hertz shares insights from the latest research along with practical advice, including why looking at information in black and white rather than in color can lead to better decisions why it's smart to be skeptical about experts' pronouncements, and how to identify the best among them why it's crucial to carve out time to think, even in moments of crisis how and why you should regulate your emotional thermostat to make smart decisions why you need to shake up your social network if you don't want only to reinforce what you already know and amplify the beliefs you already have It's time to make decisions with our eyes wide open—for the sake of our health, our wealth, and our future security.

Investing isn't a man's world anymore and that's a good thing for individual portfolios, Wall Street, and the world's financial system.Warren Buffett and the women of the world have one thing in common: They are better investors than the average man. Psychologists and scientists have shown that women have the kind of temperaments that help them achieve long-term success in the market. The calamities of the past several years have only provided more statistical and anecdotal evidence of the same. Here are just a few characteristics of female investors that distinguish them from their male counterparts:Women spend more time researching their investment choices and tend to take less risk than men do. This prevents them from chasing "hot" tips and trading on whims. Women are also more likely to seek out information that challenges their assumptions.One study found that men trade 45 percent more often than women do, and although men are more confident investors, they are also more susceptible to becoming overconfident. By trading more often and without enough research men reduce their net returns and increase transaction costs and capital gains taxes.Women aren't as susceptible to peer pressure as men are, which results in a more levelheaded, patient approach to investing.Women have less testosterone than men do (not a surprise, we know). New and continually unfolding science points to the possibility that testosterone is responsible for herdlike risk-taking behavior from men in the financial markets.This book shows that women, with their patience and good decision making, epitomize the Foolish investment philosophy, as well as the investment temperament of the most successful investor in history: Warren Buffett. While men may be brash, compulsive, and overly daring, women tend to be more studious, skeptical, and reasonable. The book will empower and educate women and the men smart enough to embrace a "feminine" investing style on how to strengthen their portfolios and find success in the market.

Did Patrizia Reggiani murder her ex-husband, Maurizio Gucci, in 1995 because his spending was wildly out of controlDid she do it because her glamorous ex was preparing to marry his mistress, Paola FranchiOr is there a possibility she didn't do it at allIn this gripping account of the ascent, eventual collapse, and resurrection of the Gucci dynasty, Sara Gay Forden takes us behind the scenes of the trial and exposes the passions, the power, and the vulnerabilities of the greatest fashion family of our times.

After commanding the Continental Army to victory in the Revolutionary War, General Washington stunned the world: He retired. Four years later, as he rode from Mount Vernon to lead the Constitutional Convention, he was the one American who could united the rapidly disintegrating country. This is the little-known story of the return of George Washington. In this groundbreaking new look at our first citizen, Pulitzer Prize–winning historian Edward J. Larson masterfully chronicles how George Washington saved the United States by coming out of retirement four years after the War of Independence to lead a country on the brink of dissolution and secure its future. Though the period between the Revolution and the Presidency has previously been neglected in studies of Washington's life, Larson's striking reassessment shows that Washington's greatness in fact rests on these years—1783 to 1789—and rightfully elevates our foremost Founding Father's "forgotten years" to a central place in the American story. In December 1783, Washington, the most powerful and popular man in America, stepped down as commander in chief and returned to private life as a farmer and landowner. Yet as Washington found happiness in successfully growing his Virginia estate, the fledgling American experiment foundered under the Articles of Confederation. Sectional bickering paralyzed government; debts went unpaid; the economy stagnated; national security was neglected; the union of states was in peril. When a Constitutional Convention was called to forge a new government, its chances of success were slim. Benjamin Franklin, James Madison, Alexander Hamilton, and other leaders realized only one American—the retired hero George Washington—could unite the fractious states. After months of anguish, Washington answered the call and left his beloved Mount Vernon in the spring of 1787 to preside over the convention in Philadelphia. Although Washington is overlooked in most accounts, Larson brilliantly uncovers Washington's vital role in shaping the Constitution—and shows, as never before, how it was only with Washington's spirited behind-the-scenes influence that the delegates passed, and the states later ratified, the founding document that has guided our government to this day. From the moment of General Washington's resignation to his victory in the first federal elections and his triumphant inauguration in New York as our first President, The Return of George Washington is a landmark work that will forever change our understanding and appreciation of America's great founder.